Transforming Growth Factor-β Signaling by Decorin
نویسندگان
چکیده
3 Chen Zhang, Chek Kun Tan, Craig McFarlane, Mridula Sharma, Nguan Soon Tan*, Ravi 4 Kambadur,*# 5 1. School of Biological Sciences, Nanyang Technological University, Singapore 637551. 6 2 Singapore Institute for Clinical Sciences, A*STAR, 30 Medical Centre Drive, National 7 University of Singapore, Singapore 8 3 Department of Biochemistry, YLL School of Medicine, National University of 9 Singapore, Singapore 10 *Equally contributing Senior Authors 11
منابع مشابه
Adenovirus-mediated decorin gene transfer prevents TGF-β-induced inhibition of lung morphogenesis.
Excessive transforming growth factor (TGF)-β signaling has been implicated in pulmonary hypoplasia associated with bronchopulmonary dysplasia, a chronic lung disease of human prematurity featuring pulmonary fibrosis. This implies that inhibitors of TGF-β could be useful therapeutic agents. Because exogenous TGF-β ligands are known to inhibit lung branching morphogenesis and cytodifferentiation ...
متن کاملDecorin GAG synthesis and TGF-β signaling mediate Ox-LDL-induced mineralization of human vascular smooth muscle cells.
OBJECTIVE Decorin and oxidized low-density lipoprotein (Ox-LDL) independently induce osteogenic differentiation of vascular smooth muscle cells (VSMCs). We aimed to determine whether decorin glycosaminoglycan (GAG) chain synthesis contributes to Ox-LDL-induced differentiation and calcification of human VSMCs in vitro. METHODS AND RESULTS Human VSMCs treated with Ox-LDL to induce oxidative str...
متن کاملEffect of Eight Weeks of Exercise with Different Intensities on the Gene Expression of Decorin and Muscular TGF-β in the Male Adult Rats
Introduction: This study aimed to investigate a period of exercise activity with different intensities on decorin gene expression through interaction with transforming growth factor-beta (TGF-β) in male adult rats. Materials & Methods: This experimental study included 24 males adult Wistar rats that were divided into three groups (8 animals per group) of High-Intensity Training (HIT), Low-In...
متن کاملIncreased decorin mRNA in diabetic mouse kidney and in mesangial and tubular cells cultured in high glucose.
The core protein of the proteoglycan decorin binds and neutralizes transforming growth factor-β (TGF-β). Activation of TGF-β is crucial to tissue injury in diabetic nephropathy, but it is not currently known whether decorin plays a role in this disease. Mouse kidney cortex demonstrates more than a twofold increase in decorin mRNA after 1, 2, 3, and 6 wk of streptozotocin diabetes. Various mouse...
متن کاملMyostatin-null mice exhibit delayed skin wound healing through the blockade of transforming growth factor-β signaling by decorin.
Myostatin (Mstn) is a secreted growth and differentiation factor that belongs to the transforming growth factor-β (TGF-β) superfamily. Mstn has been well characterized as a regulator of myogenesis and has been shown to play a critical role in postnatal muscle regeneration. Herein, we report for the first time that Mstn is expressed in both epidermis and dermis of murine and human skin and that ...
متن کاملDirected Blocking of TGF-β Receptor I Binding Site Using Tailored Peptide Segments to Inhibit its Signaling Pathway
Background: TGF-β isoforms play crucial roles in diverse cellular processes. Therefore, targeting and inhibiting TGF-β signaling pathway provides a potential therapeutic opportunity. TGF-β isoforms bind and bring the receptors (TβRII and TβRI) together to form a signaling complex in an ordered manner. Objectives: Herein, an antagonistic variant of TGF-β (AnTβ)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012